Englert Lab
Research

Here, you can find the most up-to-date research from Dr. Englert and his research team. This page is updated regularly so be on the look out for more topics and papers!

All

2023

Macrophage-Targeted Lipid Nanoparticle Delivery of microRNA-146a to Mitigate Hemorrhagic Shock-Induced Acute Respiratory Distress Syndrome.
Macrophage-Targeted Lipid Nanoparticle Delivery of microRNA-146a to Mitigate Hemorrhagic Shock-Induced Acute Respiratory Distress Syndrome.
Qinqin Fei, Emily M Shalosky, Ryelie Barnes, Vasudha C Shukla, Siying Xu, Megan N Ballinger, Laszlo Farkas, Robert J Lee, Samir N Ghadiali, Joshua A Englert
ACS nano   ·   18 Aug 2023   ·   pubmed:37595605
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.
Samuel M Brown, Christina E Barkauskas, Birgit Grund, Shweta Sharma, Andrew N Phillips, ..., Victoria J Davey, Jens D Lundgren, Abdel G Babiker, James D Neaton, H Clifford Lane
The Lancet. Respiratory medicine   ·   19 Jun 2023   ·   pubmed:37348524
Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury.
Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury.
Ana I Salazar-Puerta, María A Rincon-Benavides, Tatiana Z Cuellar-Gaviria, Julian Aldana, Gabriela Vasquez Martinez, ..., Samir Ghadiali, Diana Zepeda-Orozco, Loren E Wold, Daniel Gallego-Perez, Natalia Higuita-Castro
Advanced materials (Deerfield Beach, Fla.)   ·   05 Jun 2023   ·   pubmed:37119468
The upper and lower respiratory tract microbiome in severe aspiration pneumonia.
The upper and lower respiratory tract microbiome in severe aspiration pneumonia.
Georgios D Kitsios, Vi D Nguyen, Khaled Sayed, Nameer Al-Yousif, Caitlin Schaefer, ..., Janet S Lee, Barbara Methé, Panayiotis V Benos, Alison Morris, Bryan J McVerry
iScience   ·   06 May 2023   ·   pubmed:37250794
Macrophage-targeted lipid nanoparticle delivery of microRNA-146a to mitigate hemorrhagic shock-induced acute respiratory distress syndrome.
Macrophage-targeted lipid nanoparticle delivery of microRNA-146a to mitigate hemorrhagic shock-induced acute respiratory distress syndrome.
Qinqin Fei, Emily M Shalosky, Ryelie Barnes, Vasudha C Shukla, Megan N Ballinger, Laszlo Farkas, Robert J Lee, Samir N Ghadiali, Joshua A Englert
bioRxiv : the preprint server for biology   ·   19 Feb 2023   ·   pubmed:36824913
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
Nathan I Shapiro, Ivor S Douglas, Roy G Brower, Samuel M Brown, Matthew C Exline, ..., Jay S Steingrub, Daniel Talmor, B Taylor Thompson, Donald M Yealy, Wesley H Self
The New England journal of medicine   ·   21 Jan 2023   ·   pubmed:36688507
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study.
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study.
Tài Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragao, ..., Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G Laffey
The Lancet. Respiratory medicine   ·   21 Jan 2023   ·   pubmed:36693401
Pulmonary drug delivery for acute respiratory distress syndrome.
Pulmonary drug delivery for acute respiratory distress syndrome.
Qinqin Fei, Ian Bentley, Samir N Ghadiali, Joshua A Englert
Pulmonary pharmacology & therapeutics   ·   20 Jan 2023   ·   pubmed:36682407

2022

Ozone impairs endogenous compensatory responses in allergic asthma.
Ozone impairs endogenous compensatory responses in allergic asthma.
Kevin Ho, David Weimar, Gina Torres-Matias, Hyunwook Lee, Saaleha Shamsi, ..., Daria Jelic, Caymen M Novak, Kymberly M Gowdy, Joshua A Englert, Megan N Ballinger
Toxicology and applied pharmacology   ·   08 Dec 2022   ·   pubmed:36502870
Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation.
Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation.
Ji Young Kim, Patrick Stevens, Manjula Karpurapu, Hyunwook Lee, Joshua A Englert, ..., Navjot Pabla, Maciej Pietrzak, Gye Young Park, John W Christman, Sangwoon Chung
Frontiers in immunology   ·   26 Jul 2022   ·   pubmed:35958610
Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating
Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating
Jack Varon, Antonio Arciniegas Rubio, Diana Amador-Munoz, Alexis Corcoran, Joseph A DeCorte, ..., Alison Morris, Hyunwook Lee, Judie Howrylak, Joshua A Englert, Rebecca M Baron
Critical care explorations   ·   18 May 2022   ·   pubmed:35620769
PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation.
PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation.
Brandon W Lewis, Stephanie A Amici, Hye-Young Kim, Emily M Shalosky, Aiman Q Khan, ..., Joshua A Englert, Ned A Porter, Mitchell H Grayson, Rodney D Britt, Mireia Guerau-de-Arellano
Journal of immunology (Baltimore, Md. : 1950)   ·   14 Mar 2022   ·   pubmed:35288471
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
Hrishikesh S Kulkarni, Janet S Lee, Julie A Bastarache, Wolfgang M Kuebler, Gregory P Downey, ..., Rubin Tuder, Stefan Uhlig, Martin Witzenrath, Rachel L Zemans, Gutavo Matute-Bello
American journal of respiratory cell and molecular biology   ·   01 Feb 2022   ·   pubmed:35103557

2021

Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling.
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling.
Joseph S Bednash, Valerian E Kagan, Joshua A Englert, Daniela Farkas, Yulia Y Tyurina, ..., Oscar Rosas Mejia, Marisa Ruane-Foster, James D Londino, Rama K Mallampalli, Richard T Robinson
Translational research : the journal of laboratory and clinical medicine   ·   02 Nov 2021   ·   pubmed:34740873
mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury.
mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury.
Hyunwook Lee, Qinqin Fei, Adam Streicher, Wenjuan Zhang, Colleen Isabelle, ..., R Duncan Hite, John W Christman, Samir N Ghadiali, Rebecca M Baron, Joshua A Englert
JCI insight   ·   22 Jul 2021   ·   pubmed:34138757
Cancer Is an Independent Risk Factor for Acute Respiratory Distress Syndrome in Critically Ill Patients: A Single Center Retrospective Cohort Study.
Cancer Is an Independent Risk Factor for Acute Respiratory Distress Syndrome in Critically Ill Patients: A Single Center Retrospective Cohort Study.
Kevin Ho, Joshua Gordon, Kevin T Litzenberg, Matthew C Exline, Joshua A Englert, Derrick D Herman
Journal of intensive care medicine   ·   29 Mar 2021   ·   pubmed:33779386
Kidney-lung cross talk during ARDS: mitochondrial DAMPs join the conversation.
Kidney-lung cross talk during ARDS: mitochondrial DAMPs join the conversation.
Jack Varon, Joshua A Englert
American journal of physiology. Lung cellular and molecular physiology   ·   10 Mar 2021   ·   pubmed:33688748
Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation.
Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation.
Christopher M Bobba, Qinqin Fei, Vasudha Shukla, Hyunwook Lee, Pragi Patel, ..., Robert J Lee, John W Christman, Megan N Ballinger, Samir N Ghadiali, Joshua A Englert
Nature communications   ·   12 Jan 2021   ·   pubmed:33436554
A Novel Negative Pressure-Flow Waveform to Ventilate Lungs for Normothermic Ex Vivo Lung Perfusion.
A Novel Negative Pressure-Flow Waveform to Ventilate Lungs for Normothermic Ex Vivo Lung Perfusion.
Christopher M Bobba, Kevin Nelson, Curtis Dumond, Emre Eren, Sylvester M Black, Joshua A Englert, Samir N Ghadiali, Bryan A Whitson
ASAIO journal (American Society for Artificial Internal Organs : 1992)   ·   01 Jan 2021   ·   pubmed:32404613

2020

PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury.
PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury.
Yunjuan Nie, Teja Srinivas Nirujogi, Ravi Ranjan, Brenda F Reader, Sangwoon Chung, Megan N Ballinger, Joshua A Englert, John W Christman, Manjula Karpurapu
Journal of innate immunity   ·   12 Oct 2020   ·   pubmed:33045713
Update in Critical Care 2019.
Update in Critical Care 2019.
Yaseen M Arabi, Rama Mallampalli, Joshua A Englert, Nicholas A Bosch, Allan J Walkey, Hasan M Al-Dorzi
American journal of respiratory and critical care medicine   ·   01 May 2020   ·   pubmed:32176850
Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2.
Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2.
Sangwoon Chung, Yong Gyu Lee, Manjula Karpurapu, Joshua A Englert, Megan N Ballinger, Ian C Davis, Gye Young Park, John W Christman
American journal of physiology. Lung cellular and molecular physiology   ·   11 Mar 2020   ·   pubmed:32159972

2019

Early High-Dose Vitamin D
Early High-Dose Vitamin D
Adit A Ginde, Roy G Brower, Jeffrey M Caterino, Lani Finck, Valerie M Banner-Goodspeed, ..., Wesley H Self, Nathan I Shapiro, B Taylor Thompson, Donald M Yealy, Daniel Talmor
The New England journal of medicine   ·   11 Dec 2019   ·   pubmed:31826336
Semi-quantitative visual assessment of chest radiography is associated with clinical outcomes in critically ill patients.
Semi-quantitative visual assessment of chest radiography is associated with clinical outcomes in critically ill patients.
Stefanie E Mason, Paul B Dieffenbach, Joshua A Englert, Angela A Rogers, Anthony F Massaro, ..., Marta Vilas, Raul San Jose Estepar, George R Washko, Rebecca M Baron, Samuel Y Ash
Respiratory research   ·   12 Oct 2019   ·   pubmed:31606045
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
Marc Moss, David T Huang, Roy G Brower, Niall D Ferguson, Adit A Ginde, ..., Daniel Talmor, B Taylor Thompson, Christine A Ulysse, Donald M Yealy, Derek C Angus
The New England journal of medicine   ·   19 May 2019   ·   pubmed:31112383
Sirtuin 2 enhances allergic asthmatic inflammation.
Sirtuin 2 enhances allergic asthmatic inflammation.
Yong Gyu Lee, Brenda F Reader, Derrick Herman, Adam Streicher, Joshua A Englert, ..., Sangwoon Chung, Manjula Karpurapu, Gye Young Park, John W Christman, Megan N Ballinger
JCI insight   ·   21 Feb 2019   ·   pubmed:30668546
Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome.
Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome.
Joshua A Englert, Christopher Bobba, Rebecca M Baron
JCI insight   ·   24 Jan 2019   ·   pubmed:30674720
Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.
Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.
Joshua A Englert, Michael H Cho, Andrew E Lamb, Maya Shumyatcher, Diana Barragan-Bradford, ..., Vincent T Ho, Robert J Soiffer, Judie A Howrylak, Blanca E Himes, Rebecca M Baron
Respiratory research   ·   21 Jan 2019   ·   pubmed:30665420

2018

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Laura E Fredenburgh, Mark A Perrella, Diana Barragan-Bradford, Dean R Hess, Elizabeth Peters, ..., Charles N Serhan, Claude A Piantadosi, Rebecca M Baron, B Taylor Thompson, Augustine Mk Choi
JCI insight   ·   06 Dec 2018   ·   pubmed:30518685
FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma.
FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma.
Sangwoon Chung, Ji Y Kim, Min-Ae Song, Gye Y Park, Yong G Lee, ..., Joshua A Englert, Megan N Ballinger, Navjot Pabla, Hae Y Chung, John W Christman
Allergy   ·   05 Nov 2018   ·   pubmed:30288751
Unhinging the machinery of sepsis: An unexpected role for vascular smooth muscle.
Unhinging the machinery of sepsis: An unexpected role for vascular smooth muscle.
Joshua A Englert, John W Christman, Megan N Ballinger
Journal of leukocyte biology   ·   22 Aug 2018   ·   pubmed:30134503
Trends in 'usual care' for septic shock.
Trends in 'usual care' for septic shock.
Patrick S Hume, Jack Varon, Joshua A Englert, Shelley Hurwitz, Michael Klompas, Rebecca M Baron, Chanu Rhee
Infection control and hospital epidemiology   ·   19 Jul 2018   ·   pubmed:30022742
Bilateral Lung Masses and Dyspnea in a Young Woman.
Bilateral Lung Masses and Dyspnea in a Young Woman.
Bryan R Hay, Konstantin Shilo, Joshua A Englert
Annals of the American Thoracic Society   ·   01 Jul 2018   ·   pubmed:29957041
An Unexpected Expectoration.
An Unexpected Expectoration.
Jonathan D Casey, Joshua A Englert, Joel T Katz, Amy L Miller, Joseph Loscalzo
The New England journal of medicine   ·   01 Mar 2018   ·   pubmed:29490174

2017

Using a Novel Microfabricated Model of the Alveolar-Capillary Barrier to Investigate the Effect of Matrix Structure on Atelectrauma.
Using a Novel Microfabricated Model of the Alveolar-Capillary Barrier to Investigate the Effect of Matrix Structure on Atelectrauma.
N Higuita-Castro, M T Nelson, V Shukla, P A Agudelo-Garcia, W Zhang, S M Duarte-Sanmiguel, J A Englert, J J Lannutti, D J Hansford, S N Ghadiali
Scientific reports   ·   14 Sep 2017   ·   pubmed:28912466
Zinc deficiency primes the lung for ventilator-induced injury.
Zinc deficiency primes the lung for ventilator-induced injury.
Francis Boudreault, Miguel Pinilla-Vera, Joshua A Englert, Alvin T Kho, Colleen Isabelle, ..., Kyoung Moo Choi, Lynette Sholl, Shelley Hurwitz, Daniel J Tschumperlin, Rebecca M Baron
JCI insight   ·   02 Jun 2017   ·   pubmed:28570269
Steroids and β-Agonists in Acute Respiratory Distress Syndrome: Timing Is Everything.
Steroids and β-Agonists in Acute Respiratory Distress Syndrome: Timing Is Everything.
Joshua A Englert, Elliott D Crouser
Critical care medicine   ·   01 May 2017   ·   pubmed:28410310
Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.
Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.
Sailaja Ghanta, Konstantin Tsoyi, Xiaoli Liu, Kiichi Nakahira, Bonna Ith, ..., Laura E Fredenburgh, Joshua A Englert, Claude A Piantadosi, Augustine M K Choi, Mark A Perrella
American journal of respiratory cell and molecular biology   ·   01 Mar 2017   ·   pubmed:27636016
Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome.
Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome.
Rachel K Putman, Gary M Hunninghake, Paul B Dieffenbach, Diana Barragan-Bradford, Karolina Serhan, ..., Mizuki Nishino, Robert F Padera, Laura E Fredenburgh, Rebecca M Baron, Joshua A Englert
American journal of respiratory and critical care medicine   ·   01 Jan 2017   ·   pubmed:28035861

2016

Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney.
Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney.
Mark Hepokoski, Joshua A Englert, Rebecca M Baron, Laura E Crotty-Alexander, Mark M Fuster, Jeremy R Beitler, Atul Malhotra, Prabhleen Singh
American journal of physiology. Renal physiology   ·   09 Nov 2016   ·   pubmed:28365585
Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis.
Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis.
Joshua A Englert, Angela J Rogers
Clinics in chest medicine   ·   12 Mar 2016   ·   pubmed:27229648
Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.
Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.
Han Wei Hou, Lidan Wu, Diana P Amador-Munoz, Miguel Pinilla Vera, Anna Coronata, Joshua A Englert, Bruce D Levy, Rebecca M Baron, Jongyoon Han
Lab on a chip   ·   15 Jan 2016   ·   pubmed:26767950

2015

Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity.
Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity.
Joshua A Englert, Alvaro A Macias, Diana Amador-Munoz, Miguel Pinilla Vera, Colleen Isabelle, ..., Awapuhi Lee, Laura E Fredenburgh, Deborah J Culley, Gregory Crosby, Rebecca M Baron
Anesthesiology   ·   01 Aug 2015   ·   pubmed:26068207

2014

Circadian rhythm reprogramming during lung inflammation.
Circadian rhythm reprogramming during lung inflammation.
Jeffrey A Haspel, Sukrutha Chettimada, Rahamthulla S Shaik, Jen-Hwa Chu, Benjamin A Raby, ..., Joshua Englert, Ashley Pelton, Anna Coronata, Laura E Fredenburgh, Augustine M K Choi
Nature communications   ·   11 Sep 2014   ·   pubmed:25208554