Research
Here, you can find the most up-to-date research from Dr. Englert and his research team. This page is updated regularly so be on the look out for more topics and papers!
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2023
Macrophage-Targeted Lipid Nanoparticle Delivery of microRNA-146a to Mitigate Hemorrhagic Shock-Induced Acute Respiratory Distress Syndrome.
Qinqin Fei, Emily M Shalosky, Ryelie Barnes, Vasudha C Shukla, Siying Xu, Megan N Ballinger, Laszlo Farkas, Robert J Lee, Samir N Ghadiali, Joshua A Englert
ACS nano
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18 Aug 2023
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pubmed:37595605
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.
Samuel M Brown, Christina E Barkauskas, Birgit Grund, Shweta Sharma, Andrew N Phillips, ..., Victoria J Davey, Jens D Lundgren, Abdel G Babiker, James D Neaton, H Clifford Lane
The Lancet. Respiratory medicine
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19 Jun 2023
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pubmed:37348524
Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury.
Ana I Salazar-Puerta, María A Rincon-Benavides, Tatiana Z Cuellar-Gaviria, Julian Aldana, Gabriela Vasquez Martinez, ..., Samir Ghadiali, Diana Zepeda-Orozco, Loren E Wold, Daniel Gallego-Perez, Natalia Higuita-Castro
Advanced materials (Deerfield Beach, Fla.)
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05 Jun 2023
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pubmed:37119468
The upper and lower respiratory tract microbiome in severe aspiration pneumonia.
Georgios D Kitsios, Vi D Nguyen, Khaled Sayed, Nameer Al-Yousif, Caitlin Schaefer, ..., Janet S Lee, Barbara Methé, Panayiotis V Benos, Alison Morris, Bryan J McVerry
iScience
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06 May 2023
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pubmed:37250794
Macrophage-targeted lipid nanoparticle delivery of microRNA-146a to mitigate hemorrhagic shock-induced acute respiratory distress syndrome.
Qinqin Fei, Emily M Shalosky, Ryelie Barnes, Vasudha C Shukla, Megan N Ballinger, Laszlo Farkas, Robert J Lee, Samir N Ghadiali, Joshua A Englert
bioRxiv : the preprint server for biology
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19 Feb 2023
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pubmed:36824913
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
Nathan I Shapiro, Ivor S Douglas, Roy G Brower, Samuel M Brown, Matthew C Exline, ..., Jay S Steingrub, Daniel Talmor, B Taylor Thompson, Donald M Yealy, Wesley H Self
The New England journal of medicine
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21 Jan 2023
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pubmed:36688507
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study.
Tài Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragao, ..., Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G Laffey
The Lancet. Respiratory medicine
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21 Jan 2023
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pubmed:36693401
Pulmonary drug delivery for acute respiratory distress syndrome.
Qinqin Fei, Ian Bentley, Samir N Ghadiali, Joshua A Englert
Pulmonary pharmacology & therapeutics
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20 Jan 2023
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pubmed:36682407
2022
Ozone impairs endogenous compensatory responses in allergic asthma.
Kevin Ho, David Weimar, Gina Torres-Matias, Hyunwook Lee, Saaleha Shamsi, ..., Daria Jelic, Caymen M Novak, Kymberly M Gowdy, Joshua A Englert, Megan N Ballinger
Toxicology and applied pharmacology
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08 Dec 2022
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pubmed:36502870
Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation.
Ji Young Kim, Patrick Stevens, Manjula Karpurapu, Hyunwook Lee, Joshua A Englert, ..., Navjot Pabla, Maciej Pietrzak, Gye Young Park, John W Christman, Sangwoon Chung
Frontiers in immunology
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26 Jul 2022
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pubmed:35958610
Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating
Jack Varon, Antonio Arciniegas Rubio, Diana Amador-Munoz, Alexis Corcoran, Joseph A DeCorte, ..., Alison Morris, Hyunwook Lee, Judie Howrylak, Joshua A Englert, Rebecca M Baron
Critical care explorations
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18 May 2022
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pubmed:35620769
PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation.
Brandon W Lewis, Stephanie A Amici, Hye-Young Kim, Emily M Shalosky, Aiman Q Khan, ..., Joshua A Englert, Ned A Porter, Mitchell H Grayson, Rodney D Britt, Mireia Guerau-de-Arellano
Journal of immunology (Baltimore, Md. : 1950)
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14 Mar 2022
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pubmed:35288471
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
Hrishikesh S Kulkarni, Janet S Lee, Julie A Bastarache, Wolfgang M Kuebler, Gregory P Downey, ..., Rubin Tuder, Stefan Uhlig, Martin Witzenrath, Rachel L Zemans, Gutavo Matute-Bello
American journal of respiratory cell and molecular biology
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01 Feb 2022
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pubmed:35103557
2021
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling.
Joseph S Bednash, Valerian E Kagan, Joshua A Englert, Daniela Farkas, Yulia Y Tyurina, ..., Oscar Rosas Mejia, Marisa Ruane-Foster, James D Londino, Rama K Mallampalli, Richard T Robinson
Translational research : the journal of laboratory and clinical medicine
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02 Nov 2021
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pubmed:34740873
mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury.
Hyunwook Lee, Qinqin Fei, Adam Streicher, Wenjuan Zhang, Colleen Isabelle, ..., R Duncan Hite, John W Christman, Samir N Ghadiali, Rebecca M Baron, Joshua A Englert
JCI insight
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22 Jul 2021
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pubmed:34138757
Cancer Is an Independent Risk Factor for Acute Respiratory Distress Syndrome in Critically Ill Patients: A Single Center Retrospective Cohort Study.
Kevin Ho, Joshua Gordon, Kevin T Litzenberg, Matthew C Exline, Joshua A Englert, Derrick D Herman
Journal of intensive care medicine
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29 Mar 2021
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pubmed:33779386
Kidney-lung cross talk during ARDS: mitochondrial DAMPs join the conversation.
Jack Varon, Joshua A Englert
American journal of physiology. Lung cellular and molecular physiology
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10 Mar 2021
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pubmed:33688748
Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation.
Christopher M Bobba, Qinqin Fei, Vasudha Shukla, Hyunwook Lee, Pragi Patel, ..., Robert J Lee, John W Christman, Megan N Ballinger, Samir N Ghadiali, Joshua A Englert
Nature communications
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12 Jan 2021
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pubmed:33436554
A Novel Negative Pressure-Flow Waveform to Ventilate Lungs for Normothermic Ex Vivo Lung Perfusion.
Christopher M Bobba, Kevin Nelson, Curtis Dumond, Emre Eren, Sylvester M Black, Joshua A Englert, Samir N Ghadiali, Bryan A Whitson
ASAIO journal (American Society for Artificial Internal Organs : 1992)
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01 Jan 2021
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pubmed:32404613
2020
PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury.
Yunjuan Nie, Teja Srinivas Nirujogi, Ravi Ranjan, Brenda F Reader, Sangwoon Chung, Megan N Ballinger, Joshua A Englert, John W Christman, Manjula Karpurapu
Journal of innate immunity
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12 Oct 2020
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pubmed:33045713
Update in Critical Care 2019.
Yaseen M Arabi, Rama Mallampalli, Joshua A Englert, Nicholas A Bosch, Allan J Walkey, Hasan M Al-Dorzi
American journal of respiratory and critical care medicine
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01 May 2020
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pubmed:32176850
Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2.
Sangwoon Chung, Yong Gyu Lee, Manjula Karpurapu, Joshua A Englert, Megan N Ballinger, Ian C Davis, Gye Young Park, John W Christman
American journal of physiology. Lung cellular and molecular physiology
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11 Mar 2020
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pubmed:32159972
2019
Early High-Dose Vitamin D
Adit A Ginde, Roy G Brower, Jeffrey M Caterino, Lani Finck, Valerie M Banner-Goodspeed, ..., Wesley H Self, Nathan I Shapiro, B Taylor Thompson, Donald M Yealy, Daniel Talmor
The New England journal of medicine
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11 Dec 2019
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pubmed:31826336
Semi-quantitative visual assessment of chest radiography is associated with clinical outcomes in critically ill patients.
Stefanie E Mason, Paul B Dieffenbach, Joshua A Englert, Angela A Rogers, Anthony F Massaro, ..., Marta Vilas, Raul San Jose Estepar, George R Washko, Rebecca M Baron, Samuel Y Ash
Respiratory research
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12 Oct 2019
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pubmed:31606045
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
Marc Moss, David T Huang, Roy G Brower, Niall D Ferguson, Adit A Ginde, ..., Daniel Talmor, B Taylor Thompson, Christine A Ulysse, Donald M Yealy, Derek C Angus
The New England journal of medicine
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19 May 2019
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pubmed:31112383
Sirtuin 2 enhances allergic asthmatic inflammation.
Yong Gyu Lee, Brenda F Reader, Derrick Herman, Adam Streicher, Joshua A Englert, ..., Sangwoon Chung, Manjula Karpurapu, Gye Young Park, John W Christman, Megan N Ballinger
JCI insight
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21 Feb 2019
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pubmed:30668546
Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome.
Joshua A Englert, Christopher Bobba, Rebecca M Baron
JCI insight
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24 Jan 2019
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pubmed:30674720
Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.
Joshua A Englert, Michael H Cho, Andrew E Lamb, Maya Shumyatcher, Diana Barragan-Bradford, ..., Vincent T Ho, Robert J Soiffer, Judie A Howrylak, Blanca E Himes, Rebecca M Baron
Respiratory research
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21 Jan 2019
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pubmed:30665420
2018
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Laura E Fredenburgh, Mark A Perrella, Diana Barragan-Bradford, Dean R Hess, Elizabeth Peters, ..., Charles N Serhan, Claude A Piantadosi, Rebecca M Baron, B Taylor Thompson, Augustine Mk Choi
JCI insight
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06 Dec 2018
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pubmed:30518685
FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma.
Sangwoon Chung, Ji Y Kim, Min-Ae Song, Gye Y Park, Yong G Lee, ..., Joshua A Englert, Megan N Ballinger, Navjot Pabla, Hae Y Chung, John W Christman
Allergy
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05 Nov 2018
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pubmed:30288751
Unhinging the machinery of sepsis: An unexpected role for vascular smooth muscle.
Joshua A Englert, John W Christman, Megan N Ballinger
Journal of leukocyte biology
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22 Aug 2018
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pubmed:30134503
Trends in 'usual care' for septic shock.
Patrick S Hume, Jack Varon, Joshua A Englert, Shelley Hurwitz, Michael Klompas, Rebecca M Baron, Chanu Rhee
Infection control and hospital epidemiology
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19 Jul 2018
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pubmed:30022742
Bilateral Lung Masses and Dyspnea in a Young Woman.
Bryan R Hay, Konstantin Shilo, Joshua A Englert
Annals of the American Thoracic Society
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01 Jul 2018
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pubmed:29957041
An Unexpected Expectoration.
Jonathan D Casey, Joshua A Englert, Joel T Katz, Amy L Miller, Joseph Loscalzo
The New England journal of medicine
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01 Mar 2018
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pubmed:29490174
2017
Using a Novel Microfabricated Model of the Alveolar-Capillary Barrier to Investigate the Effect of Matrix Structure on Atelectrauma.
N Higuita-Castro, M T Nelson, V Shukla, P A Agudelo-Garcia, W Zhang, S M Duarte-Sanmiguel, J A Englert, J J Lannutti, D J Hansford, S N Ghadiali
Scientific reports
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14 Sep 2017
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pubmed:28912466
Zinc deficiency primes the lung for ventilator-induced injury.
Francis Boudreault, Miguel Pinilla-Vera, Joshua A Englert, Alvin T Kho, Colleen Isabelle, ..., Kyoung Moo Choi, Lynette Sholl, Shelley Hurwitz, Daniel J Tschumperlin, Rebecca M Baron
JCI insight
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02 Jun 2017
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pubmed:28570269
Steroids and β-Agonists in Acute Respiratory Distress Syndrome: Timing Is Everything.
Joshua A Englert, Elliott D Crouser
Critical care medicine
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01 May 2017
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pubmed:28410310
Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.
Sailaja Ghanta, Konstantin Tsoyi, Xiaoli Liu, Kiichi Nakahira, Bonna Ith, ..., Laura E Fredenburgh, Joshua A Englert, Claude A Piantadosi, Augustine M K Choi, Mark A Perrella
American journal of respiratory cell and molecular biology
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01 Mar 2017
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pubmed:27636016
Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome.
Rachel K Putman, Gary M Hunninghake, Paul B Dieffenbach, Diana Barragan-Bradford, Karolina Serhan, ..., Mizuki Nishino, Robert F Padera, Laura E Fredenburgh, Rebecca M Baron, Joshua A Englert
American journal of respiratory and critical care medicine
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01 Jan 2017
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pubmed:28035861
2016
Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney.
Mark Hepokoski, Joshua A Englert, Rebecca M Baron, Laura E Crotty-Alexander, Mark M Fuster, Jeremy R Beitler, Atul Malhotra, Prabhleen Singh
American journal of physiology. Renal physiology
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09 Nov 2016
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pubmed:28365585
Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis.
Joshua A Englert, Angela J Rogers
Clinics in chest medicine
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12 Mar 2016
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pubmed:27229648
Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.
Han Wei Hou, Lidan Wu, Diana P Amador-Munoz, Miguel Pinilla Vera, Anna Coronata, Joshua A Englert, Bruce D Levy, Rebecca M Baron, Jongyoon Han
Lab on a chip
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15 Jan 2016
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pubmed:26767950
2015
Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity.
Joshua A Englert, Alvaro A Macias, Diana Amador-Munoz, Miguel Pinilla Vera, Colleen Isabelle, ..., Awapuhi Lee, Laura E Fredenburgh, Deborah J Culley, Gregory Crosby, Rebecca M Baron
Anesthesiology
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01 Aug 2015
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pubmed:26068207
2014
Circadian rhythm reprogramming during lung inflammation.
Jeffrey A Haspel, Sukrutha Chettimada, Rahamthulla S Shaik, Jen-Hwa Chu, Benjamin A Raby, ..., Joshua Englert, Ashley Pelton, Anna Coronata, Laura E Fredenburgh, Augustine M K Choi
Nature communications
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11 Sep 2014
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pubmed:25208554